Program 2: Heart failure mechanisms & therapies
The heart chambers respond to abnormal hemodynamic stress with structural remodeling leading to functional deterioration and pathological arrhythmias. In patients with heart failure, reducing hemodynamic stressors inducing pathological remodeling are therapeutic targets, such as with valve interventions, reshaping of the heart, unloading drugs, and other therapies. Our interest is in understanding pathological remodeling of the heart to hemodynamic stress, and developing therapeutic approaches to halt or reverse such remodeling. This work is funded by grants from the American Heart Association, 14SDG20380081, 17POST33661278, 19PRE34380625.