Cardiac Remodeling in Valvular Heart Disease
Mitral regurgitation imposes a volume overload on the left ventricular chambers, stretching them out and increasing the wall stress. The chambers adapt with changes in structure and function, often resulting in heart failure and onset of arrhythmias. We are investigating these changes in a novel rodent model using a systems biology approach. Our recently published work has demonstrated that volume overload upregulates MMPs resulting in weakening of the cardiac extracellular matrix, leading to rapid and early dilatation of the LV.
Therapeutic effects of cardiac chamber reshaping in halting heart failure: One of the hallmarks of progressive and worsening heart failure is the increase in chamber volume and thinning of the myocardial walls, which work in tandem to elevate the chamber wall stress. Timely reduction of wall stress and unloading the heart has been shown to reverse these structural changes and make the heart reform its t-tubules and increase contractility. We have developed a device for percutaneous reshaping of the chamber in heart failure, and are now interested in understanding its effects at multiple scales (gene, cell, tissue, organ function).
Daisuke Onohara MD PhD
Senior research associate
Takanori Kono MD PhD
Post doctoral fellow
Daniella Corporan BS
Roberto Hernandez-Merlo DVM