PUBLICATIONS & PRESENTATIONS

  • Journal Articles
  • Conference Abstracts
  • Invited Talks
  • Editorials
  • Book Chapters
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Focus areas:   [HV] - heart valve; [HF] - heart failure; [CHD] - congenital heart disease; [Collab] - collaborations outside core focus areas
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2023

  • [HV44] Lane BA, Xu D, Suresh KS, Gleason P, Padala M. Experimental measurement of mitral valve leaflet strains after transcatheter edge to edge repair applied to correct functional mitral regurgitation. Annals of Thoracic Surgery - Short Reports, 2023, In revision.

  • [HV43] Gaidulis G, Padala M. Computational Modeling of the Subject-Specific Effects of Annuloplasty Ring Sizing on the Mitral Valve to Repair Functional Mitral Regurgitation. Annals of Biomedical Engineering, 2023, E-pub ahead of print.​

2022

  • [HV41] Delling FN, Noseworthy PA, Adams DH, Basso C, Borger M, Bouatia-Naji N, Elmariah S, Evans F, Gerstenfeld E, Hung J, Le Tourneau T, Lewis J, Miller MA, Norris RA,  Padala M , Perazzolo-Marra M, Shah DJ, Weinsaft JW, Enriquez-Sarano M, Levine RA. Research Opportunities in the Treatment of Mitral Valve Prolapse: JACC Expert Panel. JACC, 2022, 80(24):2331-2347 (PMID: 36480975)
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  • [CHD 3] Mudigonda J, Onohara D, Amedi A, Suresh KS, Kono T, Corporan D, Padala M. In vivo efficacy of a polymer layered decellularized matrix composite as a cell honing cardiovascular tissue substitute. Materials Today Bio, 2022, 17: 100451 (PMID: 36444341)
 
  • [HF7] Corporan D, Saadeh M, Yoldas A, Mudigonda J, Padala M. Passive mechanical properties of the left ventricular myocardium and extracellular matrix in hearts with chronic volume overload from mitral regurgitation. Physiological Reports, 2022, 10(14): e15305. (PMID: 35871778)
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  • [HV40] Gaidulis G, Xu D, Suresh KS, Padala M. Patient specific three dimensional ultrasound derived computational modeling of the mitral valve. Annals of Biomedical Engineering, 2022, 50(7): 847-859. (PMID: 35380321)
 
  • [CHD2] Mudigonda J, Onohara D, Xu D, Amedi A, Kono T, Wang V, Corporan D, Bhuvaneshwar G, Padala M. A biohybrid matrix with extracellular matrix core and polymeric coating as a cell honing cardiovascular tissue substitute. Frontiers in Cardiovascular Medicine, 2022, Vol 9, 807255. (PMID: 35402573)
 
  • [Collab] Sowers T, Vanderlaan D, Karpiouk A, Onohara D, Schmarkey LS, Rousselle S, Padala M, Emelianov S. In vivo safety study using radiation at wavelengths and dosages relevant to intravascular photoacoustic imaging. Journal of Biomedical Optics. 2022, Jan 27 (1): 016003 (PMID: 35102728)

2021

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  • [HF8] Kono T, Onohara D, Amedi A, Corporan D, Padala M. Effect of Early Versus Late Onset Mitral Regurgitation on Left Ventricular Remodeling in Ischemic Cardiomyopathy in an Animal Model. Journal of Thoracic and Cardiovascular Surgery. Nov 2021: S0022-5223(21)01518 (PMID: 34903384)
 
  • [HV39] Onohara D, Suresh KS, Silverman M, He Q, Kono T, Padala M. Image guided targeted mitral valve tethering with chordal encircling snares as a preclinical model of secondary mitral regurgitation. Journal of Cardiovascular Translational Research, 2021, https://doi.org/10.1007/s12265-021-10177-x. (PMID: 34618333).
 
  • [HF6] Corporan D, Segura A, Padala M. Ultrastructural adaptation of the cardiomyocyte to chronic mitral regurgitation. Frontiers in Cardiovascular Medicine, 2021, Published online 10.3389/fcvm.2021.714774. (PMID: 34733889)
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  • [HV38] Zhan-moodie S, Xu D, Suresh K, Kalra K, Onohara D, Guyton RA, Sarin EL, Padala M. Papillary muscle approximation reduces systolic tethering forces and improves leaflet mobility in the repair of functional mitral regurgitation. Journal of Thoracic and Cardiovascular Surgery - OPEN, 2021, 7, P91-104 (PMID: 35299626)

2020

  • [HV37] ​Tandon I, Johns S, Woessner A, Perez J, Cross D, Ozkizilcik A, Muldoon TJ, Vallurupalli S, Padala M, Quinn KP, Balachandran K. Label-free optical biomarkers detect early calcific aortic valve disease in wild-type mouse model. BMC Cardiovascular Disorders, 2020, 20(1): 521. (PMID: 33308143)
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  • [HV36] Xu D, McBride E, Kalra K, Wong K, Guyton RA, Sarin EL, Padala M. Undersizing mitral annuloplasty alters left ventricular mechanics in a swine model of ischemic cardiomyopathy. Journal of Thoracic and Cardiovascular Surgery. Accepted. Sept 2020 (PMID: 33288234)
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  • [HF5] Corporan D, Onohara D, Amedi A, Saadeh M, Guyton RA, Kumar S, Padala M. Hemodynamic and Transcriptomic Studies Suggest Early Left Ventricular Dysfunction in a Preclinical Model of Severe Mitral Regurgitation. Journal of Thoracic and Cardiovascular Surgery. Accepted. August 2020. (PMID: 33277035)
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  • [HF4] Onohara D, Corporan D, Kono T, Kumar S, Guyton RA, Padala M. Restoring physiological conical shape with a beating heart transcatheter implant improves left ventricular function in heart failure. Journal of Thoracic and Cardiovascular Surgery. Accepted, August 2020. (PMID: 33046233)

  • [HV35] Amedi A, Onohara D, Xu D, Suresh K, Padala M. Hemodynamic outcomes after undersizing ring annuloplasty and focal suture annuloplasty for surgical repair of functional tricuspid regurgitation. Journal of Thoracic and Cardiovascular Surgery. 2020, S0022-5223(20)32535-6. (PMID: 33041065)​
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  • [HV34] Dormer JD, Bhuiyan FI, Rahman N, Deaton N, Sheng J, Padala M, Desai JP, Fei B. Image guided mitral valve replacement: registration of 3D ultrasound and 2D X-ray images. Proc SPIE Int Soc Opt Eng, 2020, 11315, (PMID: 32528217)
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  • [Collab 2] Lindsey B, Jing B, Kim S, Collins GC, Padala M. 3D intravascular characterization of blood flow velocity fields with a forward-viewing 2D array. Ultrasound in Medicine and Biology, 2020, Sept 46(9): 2560-2571. (PMID: 32616428)
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  • [HF3] Corporan D, Kono T, Onohara D, Padala M. An image guided transapical mitral valve leaflet puncture model of controlled volume overload from mitral regurgitation in the rat. Journal of Visualized Experiments, 2020, 159: 10.3791/61029 (PMID: 32510479)
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  • [HV33] ​Elorm A, Suresh K, He Q, Onohara D, Guyton RA, Padala M. Left ventricular thinning and distension in pig hearts as a reproducible ex vivo model of functional mitral regurgitation. ASAIO Journal, 2020, Sept/Oct, 66(9):1016-1024. (PMID: 32870609)

2019

  • [HV32] Nappi F, Singh S, Padala M, Attias D, Nejjari M, Mihos C, Benedetto U, Michler R. The choice of treatment in ischemic mitral regurgitation with reduced left ventricular function. The Annals of Thoracic Surgery, 2019. E-pub ahead of print, pii: S0003-4975(19)31086-0. (PMID: 31445916)
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  • [HF2] Onohara D, Corporan D, Hernandez-Merlo RJ, Guyton RA, Padala M. Mitral regurgitation worsens cardiac remodeling in ischemic cardiomyopathy in an experimental model. Journal of Thoracic and Cardiovascular surgery, 2019, E-pub ahead of print pii: S0022-5223(19)31635-6 (PMID: 31562015)

2018

  • [HV31] Sielicka A, Sarin EL, Shi W, Sulejmani F, Kalra K, Thourani VH, Sun W, Guyton RA, Padala M. Pathological Remodeling of Mitral Valve Leaflets from Unphysiological Leaflet Mechanics after Undersized Mitral Annuloplasty to Repair Ischemic Mitral Regurgitation. Journal of the American Heart Association, 2018, 7(21):e009777. [PMID: 30571381] ​​​
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  • [HF1] Corporan D, Onohara D, Sielicka A, Hernandez-Merlo R, Padala M. Temporal changes in myocardial collagen, matrix metalloproteinases and their inhibitors in experimental chronic mitral regurgitation in rodents. American Journal of Physiology - Heart and Circulatory Physiology, 2018, Aug 24, doi: 10.1152/ajpheart.00099.2018. [Epub ahead of print] [PMID: 30141979]

  • ​​[HV30] ​Chawla S, Frater RWM, Cunnigham MJ, Padala M. Long term performance and healing of an expanded polytetrafluoroethylene multi chordal device to repair mitral leaflet flail in swine. Journal of Thoracic and Cardiovascular Surgery, 2018. E-pub ahead of print, Sept 24. doi: 10.1016/j.jtcvs.2018.07.103. [PMID: 30366754]

2017

  • [HV29] Chawla SK*, Padala M*^, W Chitwood Jr, Frater RWM. Use of a new ePTFE multi-chordal mitral apparatus (MitraPatch) to repair complex mitral valve lesions. Innovations, 2017, 12 (6): 411-417. (* co-first authors, ^ corresponding author). [PMID: 29232298]​

  • [HV28] Shi W, McIver BV, Kalra K, Schmarkey S, Sarin EL, Duggan M, Thourani VH, Guyton RA, Padala M. A swine model of percutaneous intracoronary ethanol induced acute myocardial infarction and ischemic mitral regurgitation. J Cardiovasc Transl Res. 2017 Jun 2. doi: 10.1007/s12265-017-9751-3. [Epub ahead of print] [PMID: 28577038]

2016

  • [Collab 1] ​Girish A, Padala M, Kalra K, McIver BV, Veeraswamy RK, Chen EP, Leshnower BG. The impact of intimal tear location and false lumen thrombosis in acute type-B aortic dissection, Annals of Thoracic Surgery, 2016, 102(6): 1925-1932 [PMID: 27424468]​

  • [HV27] Espiritu D, Onohara D, Kalra K, Sarin E, Padala M. Transcatheter mitral valve repair therapies - evolution, status and challenges, Annals of Biomedical Engineering, 2016, May 27[PMID: 27234818]​

  • [HV26] Sarin EL, Shi W, Duara R, Melone TA, Kalra K, Strong A, Girish A, McIver BV, Thourani VH, Guyton RA, Padala M. Swine (Sus scrofa) as a model of post-infarction mitral regurgitation and techniques to accommodate its effects during surgical repair, Comparative Medicine, 2016, 66 (4): 1-10. [PMID: 27538860]​​​
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  • [HV25] Chawla S, Shi W, McIver BV, Vinten-Johansen J, Frater RW, Padala M. Pre-clinical experience with a multi-chordal patch for mitral valve repair. Journal of Cardiovascular Translational Research, 2016, 9(2): 127-134. [PMID: 26801477]

2015

  • [HV24] Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Le Marec H, Le Tourneau T, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH; Leducq Mitral Transatlantic Network. Mitral valve disease-morphology and mechanisms. Nature Reviews Cardiology, 2015, 12(12): 689-710. [PMID: 26483167]

2014

  • [HV23] Kalra K, Wang Q, McIver BM, Shi WW, Sarin EL, Guyton RA, Sun W, Thourani VH, Padala M. Temporal changes in interpapillary muscle dynamics as an active indicator of mitral valve and left ventricular interaction in ischemic mitral regurgitation in humans, J Am Col Cardiol,2014,64 (18): 1867-1879. [PMID: 25444139]​
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  • [HV22] Kayatta MO, Jensen H, Padala M, Gilmore RC, Thourani VH. Mitral valve repair with the mitraclip, Interventional Cardiology, 2014, 6(6): 1-11. ​

  • [HV21] Miragoli M, Yacoub MH, El-Hamamsy I, Sanchez-Alonso JL, Moshkov A, Mongkoldhumrongkul N, Padala M, Paramagurunathan S, Sarathchandra P, Korchev YE, Gorelik J, Chester AH. Side specific mechanical properties of valve endothelial cells, Am J Physiology - Heart and Circulatory Physiology, 2014, Jul 1, 307(1): H15-24. [PMID: 24791787]
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  • [HV20] Padala M, Sweet M, Hooson S, Thourani VH, Yoganathan AP. Hemodynamic Comparison of Mitral Valve Repair: techniques for a flail anterior leaflet, Journal of Heart Valve Disease, 2014, 23(2): 171-176. [PMID: 25076547]
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  • [HV19] Padala M, Gyoneva LI, Thourani VH, Yoganathan AP. Impact of mitral valve geometry on hemodynamic efficacy of surgical repair in secondary mitral regurgitation, Journal of Heart Valve Disease, 2014, 23(1): 79-87. [PMID: 24779332]​​
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  • [HV18] Lam A, Clement-Guinaudeau S, Padala M, Eisner R, Thourani VH, Oshinski JO. Post Surgical Hemodynamics of Aortic Valve Bypass Operation Evaluated with Phase Contrast Magnetic Resonance Imaging, Journal of Magnetic Resonance in Medicine, 2014, 40(4): 899-905. [PMID: 24811700]

2013

  • [HV17] Thourani VH, Gunter RL, Hurst S, Kilgo P, Padala M, Puskas JD, Lattouff OM, Halkos MA, Guyton RA. Postoperative Warfarin Following Mitral Valve Repair or Bioprosthetic Valve Replacement, Journal of Heart Valve Disease, 2013, 22(5): 716-723. [PMID: 24383387]​
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  • [HV16] Padala M, Cardinau B, Gyoneva LI, Thourani VH, Yoganathan AP. Comparison of artificial neochordae and native chordal transfer in the repair of a flail posterior mitral leaflet: an experimental study, Annals of Thoracic Surgery, 2013, 95(2):629-33. [PMID: 23291143]

2012

  • [HV15] Yamauchi H, Vasilyev NV, Marx GR, Loyola H, Padala M, Yoganathan AP, del Nido PJ. Right Ventricular Papillary Muscle Approximation as a Novel Technique of Valve Repair for Functional Tricuspid Regurgitation in an Ex Vivo Porcine Model, Journal of Thoracic and Cardiovascular Surgery, 2012, 144(1):235-42 [PMID: 22341187]
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  • [HV14] Padala M, Jimenez JH, Yoganathan AP, Chin A, Thourani VH. Transapical Beating Heart Cardioscopy Technique for Off-Pump Visualization of Heart Valves, Journal of Thoracic and Cardiovascular Surgery, 2012, 144(1):231-4. [PMID: 22341423]

  • [HV13] Balachandran K, Hussain S, Yap CH, Padala M, Chester AH, Yoganathan AP. Elevated Cyclic Stretch and Serotonin Result in Degenerative Aortic Valve Remodeling via a Mechanosensitive 5HT2A Receptor Dependent Pathway, Cardiovascular Pathology, 2012, 21(3):206-13. [PMID: 21865058]​

  • [HV12] Padala M, Gyoneva LI, Yoganathan AP. Effect of anterior strut chordal transection on the force distribution on the marginal chordae of the mitral valve, Journal of Thoracic and Cardiovascular Surgery, 2012, 144(3):624-633. [PMID: 22154223]

2011

  • [HV11]Weiler M, Yap CH, Balachandran K, Padala M, Yoganathan AP. Regional analysis of dynamic deformation characteristics of native aortic valve leaflets, Journal of Biomechanics, 2011, 44(8): 1459-65. [PMID: 21458817]
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  • [HV10]Delmo Walter EM, Vasilyev NV, Sill B, Padala M, Jimenez JH, Yoganathan AP, Hetzer R, Del Nido PJ. Creation of a tricuspid valve regurgitation model from tricuspid annular dilatation using the cardioport video-assisted imaging system, Journal of Heart Valve Disease, 2011, 20:184 -188. [PMID: 21560820]

  • [HV9] Yap CH, Spinner E, Padala M, Yoganathan AP. Chapter 9 - Heart Valve Dynamics, Biomechanics - principles and practices, Edited by Donald R. Peterson and Joseph D. Bronzino, CRC Press, ISBN 978-1-4398-7098-3. ​

  • [HV8] Padala M, Keeling BW, Guyton RA, Thourani VH.  Innovations in Heart Valve Therapies, Circulation Journal, Journal of the Japanese Circulation Society, 2011, 75(5): 1028-41 (PMID: 21478626). [PMID: 21478626]

2004-2010

  • [HV7]Padala M, He Z, Sacks MS, Liou SW, Jimenez JH, Yoganathan AP. Mechanics of the mitral valve strut chordae insertion region, Journal of Biomechanical Engineering, 2010, August, 132(8): 081004. Top 10 most downloaded articles of the issue.​
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  • [HV6]Padala M, Sarin EL, Babaliaros V, Block P, Thourani VH. Engineering Review of Transcatheter Aortic Valve Technologies, Cardiovascular Engineering and Technology, 2010, March, 1(1): 77-87.
 
  • [HV5]Padala M, Hutchison R, Croft LR, Gorman JH, Gorman RC, Sacks MS, Yoganathan AP. Saddle shape of the mitral annulus reduces systolic strains on the P2 segment of the posterior mitral leaflet, Annals of Thoracic Surgery, 2009, Nov, 88(5):1499-504. [PMID: 19853100]
 
  • [HV4]Padala M, Powell SN, Croft LR, Thourani VH, Yoganathan AP, Adams DH. Mitral Valve Hemodynamics after repair of acute posterior leaflet prolapse: quadrangular resection versus triangular resection versus neochordoplasty, Journal of Thoracic and Cardiovascular Surgery, 2009 Aug; 138(2): 309-315, Highlighted on the Issue Cover Page [PMID: 19619772]
 
  • [HV3]Erek E, Padala M, Pekkan K, Jimenez JH, Yalcmbas Y, Salihoglu E, Sarioglu T, Yoganathan AP. Mitral Web – A New Concept for Mitral Valve Repair: improved engineering desigh and in-vitro studies, Journal of Heart Valve Disease, 2009, 18(3): 300-6. [PMID: 19557987]​
 
  • [CHD1] Padala M, Vasilyev N, Owen Jr JW, Dasi LP, Jimenez JH, Del Nido PJ, Yoganathan AP. Cleft Closure and Undersizing Annuloplasty Improve Mitral Repair in Atrioventricular Canal Defects, Journal of Thoracic and Cardiovascular Surgery, 2008: Nov: 136(5): 1243-9. Highlighted on the Issue Cover Page [PMID: 19026810]​
 
  • [HV2] Sucosky P, Padala M, Elhamalli A, Balachandran K, Jo H, Yoganathan AP. Design of an Ex-vivo Culture System to Investigate the Effects of Shear Stress on Cardiovascular Tissue, Journal of Biomechanical Engineering, 2008 Jun, 130 (3): 035001. [PMID: 18532871]
 
  • [HV1] Jimenez JH, Liou SW, Padala M, He Z, Sacks MS, Gorman RC, Gorman JH, Yoganathan AP. A saddle shaped annulus reduces strains in the central region of the anterior mitral valve leaflet, Journal of Thoracic and Cardiovascular Surgery, 2007 Dec; 134(6):1562-8. ​[PMID: 18023684]

2019

  • Corporan D, Hernandez-Merlo R, Onohara D, Padala M. Load independent parameters indicate early contractile dysfunction of the left ventricle despite preserved ejection fraction in an experimental model of chronic primary mitral regurgitation. 
  • Kono T, Onohara D, Corporan D, Hernandez-Merlo R, Padala M. Impact of late onset mitral regurgitation on post-ischemic left ventricular remodeling in a rodent model. 
  • Onohara D, Corporan D, Kono T, Hernandez-Merlo R, Padala M. Reducing wall stress with a trans-ventricular restraint improves systolic function and cardiac energy metabolism in a rodent ischemic cardiomyopathy model. 
  • Onohara D, Corporan D, Kono T, Hernandez-Merlo R, Guyton RA, Padala M. Reducing left ventricular sphericity with a trans-ventricular myocardial splint improves systolic function in a preclinical ischemic cardiomyopathy model. 
  • Onohara D, Corporan D, Kono T, Hernandez-Merlo R, Guyton RA, Padala M. Left ventricular cardiac reshaping with trans-myocardial splints does not impair diastolic function in preclinical studies. 
  • Agra E, Suresh K, Onohara D, Padala M. Left ventricular thinning and distension to mimic heart failure and functional mitral regurgitation in swine hearts: a platform to test new transcatheter and heart failure therapies. 
  • Suresh K, He Q, Onohara D, Kono T, Sarin EL, Padala M. Transcatheter cardiac leaflet enhancer (CARLEN) for functional mitral and tricuspid regurgitation.
  • Xu D, McBride E, Wong K, Kalra K, Padala M. Undersized mitral annuloplasty impairs diastolic relaxation mechanics of the left ventricle in a swine model of chronic ischemic mitral regurgitation. Oral presentation at the 99th annual meeting of the American Association of Thoracic Surgeons, Toronto, May 2019.
  • Onohara D, Kumar S, Corporan D, Kono T, Merlo RH, Padala M. A transventricular reshaping device (TRD) to reduce left ventricular sphericity and wall stress improves cardiac pump function in a rodent model of chronic ischemic cardiomyopathy. Oral presentation at the 99th annual meeting of the American Association of Thoracic Surgeons, Toronto, May 2019.​
  • Corporan D, Rapolu V, Padala M. Chronic mitral valve regurgitation alters passive mechanical properties of the left ventricular myocardium in the rodent model. Oral presentation at the annual meeting of the Heart Valve Society, Sitges, April 2019.
  • Mudigonda J, Xu D, Wang V, Padala M. In vitro and in vivo assessment of an electrospun nanofiber coated decellularized bovine pericardium as a regenerative valve substitute vs. glutaraldehyde fixed pericardium. Oral presentation at the annual meeting of the Heart Valve Society, Sitges, April 2019.
  • Sielicka A, Amedi A, Padala M. Transforming growth factor beta induced mitral valve interstitial cell activation and phenotypic shift is differentially inhibited by a TGF-beta upstream blocker (Losartan) and a TGF-beta receptor blocker (SB505124). Poster competition at the annual meeting of the Heart Valve Society, Sitges, April 2019.​

2018

  • Onohara D, Hernandez-Merlo R, Onohara D, Guyton RA, Padala M. A Trans-Ventricular Restraint To Reshape And Reduce The Left Ventricle Halts Chronic Adverse Remodeling In A Rodent Model Of Ischemic Cardiomyopathy, Poster presentation at the 2018 Scientific Sessions of the American Heart Association, Chicago, Nov 10-12, 2018.
  • Suresh K, Padala M. A Percutaneously Delivered Leaflet Extending Implant to Correct Mitral Regurgitation: Feasibility and Safety Study in Ex Vivo and Swine Models. Oral presentation at the 2018 World Congress of Biomechanics, Dublin, Ireland, Jul 8-12th, 2018.
  • Sielicka A, Padala M. Unphsyiological Mitral Leaflet Biomechanics after Surgical Repair Induces Progressive Leaflet Thickening and Fibrosis via the TGF-beta Pathway in a Chronic Porcine Model. Oral presentation at the 2018 World Congress of Biomechanics, Dublin, Ireland, Jul 8-12th, 2018.
  • Padala M, Kalra K. Temporal Changes in Interpapillary Muscle Dynamics as an Active Indicator of Mitral Valve and Left Ventricular Interaction in Ischemic Mitral Regurgitation. Oral presentation at the 18th US National Congress for Theoretical and Applied Mechanics, June 4-8, 2018. Chicago, IL.​
  • Suresh K, He Q, Padala M. A biomaterial covered implant for in situ tissue engineered extension of mitral valve leaflets to repair mitral regurgitation. Oral presentation at the International Conference of Tissue Engineered Heart Valves, Amsterdam, Netherlands. May 18, 2018.
  • Sielicka A. Padala M. Fibrosis and Disruption of Trilayered Structure are Evident in Mitral Valve Leaflets Explanted from Swine that Underwent Undersizing Mitral Annuloplasty for Repair of Ischemic Mitral Regurgitation. Oral presentation at the AATS 98th annual meeting, San Diego, CA. April 28-May 1, 2018.
  • Suresh K, He Q, Padala M. A flexible posterior leaflet extending implant eliminates functional mitral regurgitation in a swine model. Moderated poster presentation at the 4th annual meeting of the Heart Valve Society, New York City, April 12-14, 2018.
  • Corporan D, Onohara D, Hernandez-Merlo R, Padala M. Pathological expression of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in a volume overloaded left ventricle from chronic mitral valve regurgitation. Moderated poster presentation at the 4th annual meeting of the Heart Valve Society, New York City, April 12-14, 2018.
  • Sielicka A, Padala M. Changes in the structure and overall thickness of the anterior and posterior mitral valve leaflets after undersizing mitral annuloplasty to repair ischemic mitral regurgitation. Oral presentation at the 4th annual meeting of the Heart Valve Society, New York City, April 12-14, 2018.
  • Mudigonda J, Padala M. Polycaprolactone-chitosan nanofibers electrospun on decellularized bovine pericardium as a regenerative biomaterial for heart valve tissue replacement. Oral presentation at the 4th annual meeting of the Heart Valve Society, New York City, April 12-14, 2018.
  • Mudigonda J, Padala M. Polycaprolactone-chitosan nanofibers electrospun on decellularized bovine pericardium as a regenerative biomaterial for heart valve tissue replacement. Oral presentation at the 2018 Regenerative Medicine Workshop at Charleston, March 21-24, 2018.

2017

  • Chawla SK, Padala M, Thourani VH, Frater RWM. In-vivo efficacy of an ePTFE apparatus for mitral valve reconstruction. Oral presentation in the novel approaches and technologies session, Mitral Conclave 2017, New York City, April 2017
  • ​​Padala M, Suresh K, Sarin EL. A Leaflet Extending Device For Easier Repair Of Functional Mitral Regurgitation With Minimally Invasive Techniques. Oral presentation at the annual meeting of the International Society of Minimally Invasive Cardiothoracic Surgery, Rome, Italy. June 2017.
  • ​Sielicka A, Espiritu D, Shi W, Thourani VH, Guyton RA, Sarin EL, Padala M. Transforming growth factor beta genes are upregulated and collagen synthesis is elevated in mitral valve leaflets after undersizing mitral annuloplasty to repair ischemic mitral regurgitation. Poster presentation at the William C. Wood Research Symposium, Department of Surgery, Emory University, March 30, 2017.
  • Onohara D, Espiritu D, Hernandez-Merlo R, Thourani VH, Sarin EL, Guyton RA, Padala M. Functional and Structural Differences in Left Ventricular Remodeling to Heart Failure in Primary and Secondary Mitral Regurgitation. Poster presentation at the William C. Wood Research Symposium, Department of Surgery, Emory University, March 30, 2017.
  • ​Onohara D, Espiritu D, Shi W, Hernandez-Merlo R, Thourani VH, Sarin EL. Guyton RA, Padala M. Functional and structural differences in left ventricular remodeling in primary and secondary mitral regurgitation. Oral presentation at the Heart Valve Society Meeting, Grimaldi Forum, Monaco, March 2-4, 2017. 
  • ​Sielicka A, Espiritu D, Shi W, Thourani VH, Guyton RA, Sarin EL, Padala M. Transforming growth factor beta genes are upregulated and collagen synthesis is elevated in mitral valve leaflets after undersizing mitral annuloplasty to repair ischemic mitral regurgitation. Oral presentation at the Heart Valve Society Meeting, Grimaldi Forum, Monaco, March 2-4, 2017. 
  • ​Espiritu D, Onohara D, Padala M. Transcriptional differences in left ventricular extracellular matrix remodeling in primary and secondary mitral regurgitation. Oral presentation at the Heart Valve Society Meeting, Grimaldi Forum, Monaco, March 2-4, 2017. 
  • ​​Tellez A, Hemming K, Vasanji A, Kaufman ZJ, Hoover BA, Padala M, Brady DA, Rousselle SD.Novel Preclinical Assessment of Transcatheter Mitral Valve Replacement by Micro-Computed Tomography: µCT Imaging-Guided Histopathological Evaluation. Poster presentation at the Annual Meeting of the American College of Cardiology (ACC), March 17-19, 2017, Washington DC.

2016

  • Onohara D, Shi W, Hernandez-Merlo D, Thourani VH, Sarin EL, Guyton RA, Padala M. Divergent Left Ventricular Remodeling Pathways in Chronic Primary and Secondary Mitral Regurgitation. Accepted for Oral Presentation and Finalist for the Vivien Thomas Young Investigator Award, Scientific Sessions, American Heart Association, Nov 12-16, New Orleans.
  • Sielicka A, Sarin EL, Shi W, Espiritu D, Thourani VH, Guyton RA, Padala M. Fibrotic remodeling and stiffening of mitral valve leaflets after undersizing ring annuloplasty to correct ischemic mitral regurgitation. Accepted for oral presentation in the Mitral Valve Surgery: Innovations Galore session at the Scientific Sessions of the American Heart Association 2016, New Orleans, Nov 12-16
  • ​Padala M, He Q, Suresh K, Sarin E. MitraPlug - A transcatheter mitral leaflet extender for mitral valve repair, Oral presentation at the Transcatheter Cardiac Therapeutics (TCT) annual meeting, October 29 - Nov 2, 2016. Washington DC.
  • ​​Espiritu D, Suresh K, He Q, Onohara D, Padala M. A Robust Ex-vivo Functional Mitral Valve Model to Test Novel Transcatheter Mitral Valve Devices. To be presented at the Transcatheter Cardiac Therapeutics (TCT) annual meeting, October 29 - Nov 2, 2016. Washington DC.
  • ​​Sielicka A, Sarin EL, Shi W, Thourani VH, Guyton RA, Padala M. Mitral leaflet fibrosis after undersized ring annuloplasty to repair ischemic mitral regurgitation. To be presented at the 7th biennial Heart Valve Biology and Tissue Engineering Meeting. Sea Pines Resort, Hilton Head Island, SC, USA. 12-14th October, 2016.
  • Padala M. Mechanobiology in heart valve disease and associated heart failure.  Featured speaker at the 7th biennial Heart Valve Biology and Tissue Engineering Meeting. Sea Pines Resort, Hilton Head Island, SC, USA. 12-14th October, 2016.
  • ​​​Padala M. Heart valve structure and function - implications for valve disease. Lecture at the 2nd annual meeting of the Heart Valve Society, New York. March 17-19, 2016.

2015

  • Shi W, Girish A, Bhushan S, Padala M. Impact of mitral regurgitation on left ventricular remodeling in ischemic cardiomyopathy. Accepted for presentation at the 2015 Scientific Sessions of the American Heart Association, Nov 7-11, Orlando, Florida.
  • Kalra K, Padala M. Cardiac MRI derived forward stroke energy is a better index of left ventricular pump function over ejection fraction in mitral regurgitation. Accepted for presentation at the 2015 Scientific Sessions of the American Heart Association, Nov 7-11, Orlando, Florida. 
  • ​Girish A, Padala M, Kalra K, Chen E, Veeraswamy R, Leshnower BG. Partial false lumen thrombosis results in an increase in false lumen pressure in an ex-vivo porcine model of type B aortic dissection. Oral presentation at the 62nd annual meeting of the Southern Thoracic Surgical Society, Nov 4-7, Florida. 
  • ​Bhushan S, Girish A, Shi W, Padala M. A rodent model to compare the effect of mitral regurgitation on left ventricular remodeling. Poster presentation at the Inaugural scientific meeting of the Heart Valve Society, Monaco. 
  • Padala M. Repair for functional MR - thinking beyond the annulus. Lecture at the Inaugural scientific meeting of the Heart Valve Society, Monaco. 
  • Padala M, Shi W, Duara R, Kalra K, Guyton RA,Thourani VH, Sarin EL. Intra-ventricular papillary muscle banding is an effective technique to repair ischemic mitral regurgitation in dilated ventricles: comparison with mitral annuloplasty in a chronic swine model. Oral presentation at the 95th AATS Annual Meeting, Seattle. (webcast link)​

2014

  • Padala M, Kalra K, Shi W, Wang Q, Guyton RA, Sun W, Thourani VH, Sarin EL. Intraventricular papillary muscle banding vs. undersized mitral annuloplasty to treat ischemic mitral regurgitation - acute outcomes. Oral presentation at the AHA Scientific Sessions, Chicago, Nov 15-19, 2014.
  • Padala M, Zamani MH, Sarathchandra P, Merot J, Gorelik J, Yacoub MH, Chester AH. Filamin-A mutations causing mitral valve prolapse alters integrin expression and causes breakdown of mechanotransduction. Poster talk and presentation at the AHA Scientific Sessions, Chicago, Nov 15-19, 2014.
  • ​Chadid TS, Kalra K, Eisner R, Sarin EL, Guyton RA, Thourani VH, Padala M. Left circumflex scar burden quantified using cardiac MRI predicts severity of ischemic mitral regurgitation and postoperative mortality. Oral presentation at the 2014 clinical congress of the American College of Surgeons, San Francisco, CA. Oct 26-30, 2014.
  • Kalra K, Guyton RA, Thourani VH, Padala M. Effect of mitral regurgitation severity and extent of leaflet tethering on leaflet remodeling in ischemic mitral regurgitation. Oral presentation at the 6th Biennial Meeting on Heart Valve Biology and Tissue Engineering, London, United Kingdom, Sept 10-12, 2014.  
  • Padala M, Zamani MH, Sarathchandra P, Merot J, Gorelik J, Yacoub MH, Chester AH. Filamin-A mutations causing mitral prolapse alter integrin expression and cellular mechanotransduction. Oral presentation at the 6th Biennial Meeting on Heart Valve Biology and Tissue Engineering, London, United Kingdom, Sept 10-12, 2014.​
  • ​Padala M. Mitral-Plug: a transcatheter solution to mitral valve repair in ischemic heart disease. Oral presentation at the Innovation Day at EuroPCR, Paris, France, May 2014.

2013

  • Kalra K, McIver B, Shi W, Guyton RA, Thourani VH, Padala M. Temporal Changes In Inter Papillary Muscle Distance As An Active Indicator Of Ventricular-valvular Interaction In Functional Mitral Regurgitation In Humans, Poster Presentation at the Scientific Sessions 2013 of the American Heart Association, Dallas, Nov 2013.
  • Padala M, McIver B, Shi W, Vinten-Johansen J, Thourani VH, Guyton RA. Quantitative assessment of a clinically relevant large animal model of advanced heart failure with severe functional mitral regurgitation, Oral presentation at the 7th Biennial Congress of the Society of Heart Valve Disease, Venice, Italy, June 2013.
  • Padala M, Torii R, Moharem S, McIver B, Chester AH, Donya M, Elguindy A, Afifi AM, Yacoub MH. Flow induced remodeling of the anterior mitral leaflet after tailored relief of LVOT obstruction in hypertrophic obstructive cardiomyopathy (HOCM), Oral presentation at the 7th Biennial Congress of the Society of Heart Valve Disease, Venice, Italy, June 2013.
  • Zamani M, Padala M, Sarathchandra P, Yacoub MH, Chester AH. The role of integrins in regulation of the stiffness in mitral valve leaflets, Oral presentation at the 7th Biennial Congress of the Society of Heart Valve Disease, Venice, Italy, June 2013.
  • Kalra K, McIver B, Shi WW, Vinten-Johansen J, Thourani VH, Guyton RA, Padala M. Mitral valve remodeling in functional mitral regurgitation, Oral presentation at the 7th Biennial Congress of the Society of Heart Valve Disease, Venice, Italy, June 2013.
  • McIver B, Shi W, Vinten-Johansen J, Thourani VH, Guyton RA, Padala M. Paradoxical septal motion causes tricuspid regurgitation after a left ventricular inferior wall infarction, Oral presentation, 7th Biennial Congress of the Society of Heart Valve Disease,Venice,Italy,June 2013.
  • Kalra K, McIver B, Shi WW, Eisner RL, Guyton RA, Thourani VH, Padala M. Intraventricular segmental dyssynchrony as a mechanism of ischemic mitral regurgitation, Poster presentation at the Emory Department of Surgery Research Symposium, June 2013.

2012

  • Zamani M, Sarathchandra P, Padala M, Latif N, Yacoub MH, Chester A. Integrins regulate the stiffness of mitral valve leaflets. Scientific Sessions of the American Heart Association, Oral Presentation, Los Angeles, CA, Nov 2012.
  • Hussain S, McIver BV, Puskas JD, Halkos MA, Guyton RA, Thourani VH, Padala M. Imbalance in Extracellular Matrix Synthesis and Degradation as a Mechanism of Leaflet Weakening in Sporadic Mitral Valve Prolapse in Humans. 5th Biennial Heart Valve Biology and Tissue Engineering Conference, Mykonos, Greece, May 2012
  • McIver B, Hussain S, Thourani VH, Padala M. Adaptation of the Mitral Valve to Chronic Ischemic Left Ventricular Failure in Swine. 5thBiennial Heart Valve Biology and Tissue Engineering Conference, Greece, May 2012

2011

  • Padala M, Sacks MS, Thourani VH, Yoganathan AP. Mechanics of the Strut Chordae to Anterior Leaflet Transition Zone in Normal, Prolapsing and Tethered Mitral Valve, Poster presentation at the Biennial Meeting of the Society of Heart Valve Disease, Barcelona, June 2011.
  • Thourani VH, Sharma J, Padala M, Yan H. Elevated Parathyroid Hormone Predicts Short and Long Term Mortality in Dialysis Patients Undergoing Valve Surgery, Oral presentation at the Biennial Meeting of the Society of Heart Valve Disease, Barcelona, June 2011.
  • Thourani VH, Kilgo P, Padala M, Guyton RA. Long Term Outcomes are improved in Elderly Patients Undergoing Mitral Valve Repair Compared to Mitral Valve Replacement, Oral presentation at the Biennial Meeting of the Society of Heart Valve Disease, Barcelona, June 2011.
  • Thourani VH, Hurst S, Kilgo P, Padala M, Guyton RA. Postoperative Warfarin Following Mitral Valve Repair or Bioprosthetic Valve Replacement Does not Reduce Short Term Stroke Risk, Oral presentation at the Biennial Meeting of the Society of Heart Valve Disease, Barcelona, June 2011.
  • Vasilyev NV, Padala M, Delmo Walter EM, Sill N, Thourani VH, Jimenez JH, Yoganathan AP, del Nido PJ. Functional and Hemodynamic Assessment of a Novel 3-Dimensional Anatomically Correct Annuloplasty Ring to Correct Functional Tricuspid Regurgitation, Oral presentation at the Biennial Meeting of the Society of Heart Valve Disease, Barcelona, June 2011.
  • Haruo Y, Vasilyev NV, Gerald M, Loyola H, Padala M, Yoganathan AP, del Nido PJ. Right Ventricular Papillary Muscle Approximation toward Ventricular Septum as a Simple technique for Repair of Tricuspid Regurgitation: An Ex Vivo Study, Oral presentation at the 11th annual meeting of the International Society of Minimally Invasive Cardiothoracic Surgery (ISMICS), Jun 8-11, Washington DC, District of Columbia. 
  • Padala M, Thourani VH, Guyton RA, Yoganathan AP. “Functional Efficacy of Neochordoplasty vs. Chordal Translocation for Surgical Repair of Acute Posterior Leaflet Prolapse”, Mitral Conclave of the American Association of Thoracic Surgeons, May 4-6, New York.
  • Padala M, Rabbah JP, Thourani VH, Guyton RA, Yoganathan AP. “Reducing Posterior Leaflet Tethering Using Patch Augmentation Improves Leaflet Mobility and Systolic Coaptation Length in Ischemic Mitral Regurgitation”, Mitral Conclave of the American Association of Thoracic Surgeons, May 4-6, New York, NY.
  • Padala M, Thourani VH, Yoganathan AP. “ A Novel Tricuspid Annuloplasty Repair System”, South East Medical Device Association Annual Conference, March 29-30, Atlanta, GA.

2019

  • ​Left ventricular remodeling to heart failure in response to hemodynamic stress: from mechanisms to interventional therapies. Invited lecture at the 17th international conference on biomedical engineering, National University of Singapore, December 2019.
  • Integrated approach for patient specific modeling. Invited talk in the Networked HVD research: today and tomorrow, 5th annual meeting of the Heart Valve Society, Sitges, Spain. April 2019
  • Modeling and mitral valve surgery. Invited talk in the Congenital Mitral Valve disease session, 5th annual meeting of the Heart Valve Society, Sitges, Spain. April 2019
  • ​Biomechanics in the Pathogenesis and Treatment of Valvular Heart Disease and Heart Failure: Mechanistic Insights to Therapeutic Devices, Wallace H. Coulter Dept of Biomedical Engineering, Georgia Tech/Emory. Jan 2019.​

2018

  • Ischemic mitral regurgitation - mechanisms to therapies. Grand rounds, Emory Heart and Vascular Center, Nov 2018.
  • Papillary muscle repositioning effects on the LV in ischemic mitral regurgitation. Invited speaker at the 4th Annual meeting of the Heart Valve Society, NY, April 12-14, 2018.

2017

  • Padala M. Research in Cardiovascular Innovations: the key is collaboration, Invited faculty lecture in the Early Career Education Session by the Cardiovascular Surgery and Anesthesia Council, Scientific Sessions of the American Heart Association, Nov 2017, Anaheim, CA.
  • Padala M. Functional mitral regurgitation - mechanisms, therapies and opportunities. Invited seminar speaker. Star Hospitals Cardiovascular Institute. Hyderabad, India, Aug 2017.
  • Padala M. Engineering in the evolution of cardiac surgery. Guest lecturer in the bio-fluid mechanics undergraduate course, Georgia Institute of Technology, 2017. 
  • Padala M. Functional mitral regurgitation: from physiology to therapies. Invited seminar speaker, Division of Cardiothoracic Surgery, University of Maryland, MD, February 2017.

2016

  • Padala M. Mechanobiology of heart valves, Key note speaker at the Biennial Heart Valve Biology and Tissue Engineering meeting, Hilton Head, October 2016.
  • Padala M. Heart valve structure to function. Invited faculty lecture at the 2nd annual meeting of the heart valve society, New York, March 16-19, 2016.
  • Padala M.  Valvular disease and heart failure - a mechanobiology perspective, guest lecturer in the cardiovascular biomechanics graduate level course, Georgia Institute of Technology, 2016.
  • Padala M. Functional mitral regurgitation - mechanisms to therapies. Invited faculty presenter at the Heart and Vascular Grand Rounds, Carlyle Fraser Heart Center, Division of Cardiology, Emory University, 2016.

2015

  • Padala M. Repair for functional mitral regurgitation - thinking beyond the annulus. Invited faculty lecture at the scientific session of the Heart Valve Society, Monaco, May 2015.

2014

  • Padala M. Side cell population and valve repair. Invited faculty lecture in the Didactic symposia: strategies for cardiovascular repair - discovery and debate, TCT 2014, Washington DC.
  • Padala M. Ideas for tomorrow in 3D echocardiography, Invited faculty lecture in the echo 360 conference, Piedmont Healthcare, Atlanta, GA​

2021

  • Gaidulis G, Padala M. Biomechanics of the pulmonary autograft after the Ross procedure. Journal of Thoracic and Cardiovascular Surgery, 2021, Accepted. (PMID: pending)
  • ​Silverman M, Padala M. Transaortic mitral valve repair with edge to edge technique. Seminars in Thoracic and Cardiovascular Surgery, 2021, Aug 15, S1043-0679(21)00382. (PMID: 34407433).
  • Padala M. Functional mitral stenosis after undersizing mitral annuloplasty for ischemic mitral regurgitation - ignoring the elephant in the room. Seminars in Thoracic and Cardiovascular Surgery, 2021, May 15:S1043-0679(21)00229-X. (PMID: 34004299)
  • Padala M. Quantifying paravalvular aortic regurgitation after transcatheter aortic valve replacement - correlative indices vs. causative factors. Seminars in Thoracic and Cardiovascular Surgery, 2021, Feb 18:S1043-0679(21)00078-2. (PMID: 33610696)​​

2020

  • ​Xu D, Padala M. The mitral valve and the left ventricle in functional mitral regurgitation - the puppet and the puppeteer. Journal of Thoracic and Cardiovascular Surgery - OPEN, 2020, Vol 5, p63-65.
  • Silverman M, Padala M. Simple and effective subvalvular repair of ischemic mitral regurgitation - Yes, we can!. Journal of Thoracic and Cardiovascular Surgery - Techniques, 2020, Vol 4, p138-139.
  • Silverman M, Padala M. Multifaceted challenges with choosing between mitral valve repair and replacement in rheumatic heart disease. Journal of Thoracic and Cardiovascular Surgery, 2020, Aug 15;S0022-5223(20)32404-1. (PMID: 33246568).
  • ​Padala M. When all roads lead to the heart, which one to choose? Journal of Thoracic and Cardiovascular Surgery, 2020, Jun 5;S0022-5223(20)31311-8. (PMID: 32711991)
  • Kalra K, Padala M. Pouring life into dead tissues - a brief history of the porcine small intestine submucosa (SIS) in cardiovascular surgery: success, failures, hype and hope. Journal of Thoracic and Cardiovascular Surgery, 2020, Oct 160(4): e217-219 (PMID: 31898958).

2010 - 2019

  • Padala M. Stress in the time of transcatheter aortic valve replacement. Journal of Thoracic and Cardiovascular Surgery, 2019, pii: S0022-5223(18)32906-4. (PMID: 30527746)​
  • Padala M. Aortic root anatomy as a factor in the fluid mechanics of transcatheter aortic valve replacement. Journal of Thoracic and Cardiovascular Surgery, 2018, S0022-5223(18)32867-8. (PMID: 30527722)
  • Padala M. The heart valve is no stronger than its weakest link: the need to improve durability of pericardial leaflets. Journal of Thoracic and Cardiovascular Surgery, 2018, 156(1): 207-208. (PMID: 29636190)
  • Padala M. Patient specific computational biomechanical modeling to guide mitral valve repair strategy: practicality and value. Journal of Thoracic and Cardiovascular Surgery, 2018, 155(2): 606-607 [PMID: 29415388]
  • Padala M. The arithmetic of a successful mitral valve repair. Journal of Thoracic and Cardiovascular Surgery, 2017, 154(5): 1638-1640 [PMID: 28888372]
  • ​Padala M. Invited commentary on Undersizing mitral annuloplasty increases strain in the proximal lateral left ventricular wall, Annals of Thoracic Surgery, 2017, March, 103(3): 827 [PMID: 28219548].
  • Padala M. Papillary muscle approximation is an anatomically correct repair for ischemic mitral regurgitation, Journal of the American College of Cardiology, 2016, 68 (10): 1146-1147. [PMID: 27585516].
  • Padala M. Biomaterials for heart valve replacement: conjectures and refutations, Invited editorial,  Journal of Thoracic and Cardiovascular Surgery, 2016, Oct, 152 (4): 1175-6. [PMID: 27349286]. 
  • Padala M. Invited commentary on Moderate ischemic mitral regurgitation after postero-lateral myocardial infarction in sheep alters left ventricular shear but not normal strain in the infarct and infarct border zone, Annals of thoracic surgery, 2016, 101, e211. [PMID: 27211984]
  • Guyton RA, Padala M. TAVR in bicuspid aortic stenosis - Early Success but Concerning Red Flags, JACC - Cardiovascular Interventions, 2016; 9(8):825-827. [PMID: 27101907]
  • Padala M, Invited commentary on Preoperative three-dimensional valve analysis predicts recurrent ischemic mitral regurgitation after mitral annuloplasty,  Annals of Thoracic Surgery, 2016, 101(2): 575. [PMID: 26777921]
  • Saikrishnan N, Siefert AW, Rabbah JP, Padala M, Yoganathan AP. Letter regarding the article by Vismara et al. published in Int J Artif Organs 2011: 34(4): 383-391, International Journal of Artificial Organs, 2012, 35(2): 158-9. [PMID: 22395916]​​
  • Yap CH, Spinner E, Padala M, Yoganathan AP. Heart Valve Dynamics, Chapter 16 in the biomedical engineering handbook - edited by Joseph D. Bronzino, Donald R. Peterson, CRC Press - Taylor and Francis Group.